Use a swab to apply a thin film of clindamycin to affected area q12hr. Antibiotic therapy in patients with renal impairment books overview. The use of ideal body weight has been shown to be associated with a more predictable muscle strength recovery within 60 minutes and a lack of need for antagonism compared to total body weight. Refer to renal pharmacist or medicines information for advice on dosing in haemodialysis and peritoneal dialysis. The success of nitrofurantoin therapy depends on achieving adequate urinary concentrations of the drug.
Cleocin clindamycin may treat, side effects, dosage, drug interactions. Tables of antibacterial drug dosages red book 2018 red book. Clindamycin is also used in the treatment of streptococcal pharyngitis, acne vulgaris. For bacterial vaginosis, cleocin cream or suppository products are inserted vaginally once daily before bedtime. Clindamycin is an antibiotic used for the treatment of a number of bacterial infections, including bone or joint infections, pelvic inflammatory disease, strep throat, pneumonia, middle ear infections, and endocarditis. The advice on dosing in renal impairment linked from this page has mainly been taken from the renal drug handbook 3rd edition. Antibiotic renal dosing list with the age of antibiotic scrutiny upon us and cms starting to put antibiotics under the microscope, remedi seniorcare is happy to provide you with this antibiotic renal dosing list to help you stay compliant. Clindamycin dosage modification may not be necessary in patients with renal disease. Cleocin phosphate should not be injected intravenously undiluted as a bolus, but should be infused over at least 1060 minutes as directed in the dosage and administration section. The adjustments listed in the dosing guidelines will be made unless the. Drug dosing adjustments in patients with chronic kidney disease myrna y. Adult drugs analgesics antihypertensive and cardiovascular agents antimicrobial agents miscellaneous agents sedatives, hypnotics, and other drugs used in.
The following information includes only the average doses of this medicine. The renal drug handbook the st georges hospital, adult critical. The information on dosage adjustments in renal impairment given in this book is based on. Follow your doctors orders or the directions on the label. Clindamycin is a lincosamide antibiotic that has been approved by the us food and drug administration fda for the treatment of anaerobic, streptococcal, and staphylococcal infections.
May adjust dose as necessary not to exceed 40 mgkgday. Hemodialysis and peritoneal dialysis are not effective in removing. More severe infections 300 to 450 mg every 6 hours. This book is distributed under the terms of the creative commons. Macrobid nitrofurantoin macrocrystalsnitrofurantoin. Clindamycin may be acceptable for use during pregnancy. Esrd crcl 90, 6089, 3059, 1529, intravenous piggyback. Treatment with antibacterial agents alters the normal flora of the colon, leading to overgrowth of c. Comprehensive update to antimicrobial renal dosing document.
Dosing guidelines for adults and children, 5th, american college of physicians, 2007. Ciprofloxacin, cisatracurium, cisplatin, cladribine, clarithromycin, clindamycin, clonidine, codeine, cyclophosphamide, cyclosporine, cytarabine, dapsone. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. Dosing recommendations are based on creatinine clearance calculated using the cockcroftgault equation. It can also be used to treat acne, and some cases of methicillinresistant staphylococcus aureus mrsa. What are the most likely bugs based on the infection site. Cidofovir, cilazapril, cimetidine, ciprofloxacin, cisapride, cisplatin, cladribine, clarithromycin, clemastine, clindamycin, clodronate, clofazamine, clofibrate. Its major disadvantage is its propensity to cause antibioticassociated diarrhea, including clostridioides formerly clostridium difficile colitis.
Pediatric patients for children who are able to swallow capsules. Cleocin, clindesse clindamycin dosing, indications. A process for assigning all renal patients medication dosing to a pharmacist leaves prescribers more time for other clinical activities and may decrease the risk of adverse drug events. Data sources include ibm watson micromedex updated 4 may 2020, cerner multum updated 4 may 2020. The antibiotic dose for continuous renal replacement therapy d crrt should. A catalogue record for this book is available from the british library. Munar, pharmd, bcps, and harleen singh, pharmd oregon state university college of pharmacy, portland, oregon. Discontinue therapy permanently and institute appropriate therapy if anaphylactic or severe hypersensitivity reaction occurs.
The use of cleocin pediatric occasionally results in overgrowth of nonsusceptible organismsparticularly yeasts. In it you will find renal doses of numerous antibiotics based on your. Serum halflife of clindamycin is increased slightly in patients with markedly reduced renal function. Clindamycin, sobelin, 3, 3, 900, 600, 68, 600, 68, 600, 68, 600, 600, 68. Perhaps a consideration for future editions might be to include some general comments on the use of. There is a slightly less than proportional increase for pioglitazone and total pioglitazone at a dose of 60 mg per day. In patients with ckd stages 1 through 5 predialysis, the cockcroftgault cg equation see chapter. Pediatric drugs analgesics antihypertensive and cardiovascular agents antimicrobial agents miscellaneous agents sedatives, hypnotics, and other drugs used in psychiatry. Should superinfections occur, appropriate measures should be taken as indicated by the clinical situation. Cleocin t topical lotion containing clindamycin phosphate equivalent to 10 mg clindamycin per milliliter is available in the following size.
Dosing intervals of every 6 or 8 hours are most commonly used in pediatric practice. Clostridium difficile associated diarrhea cdad has been reported with use of nearly all antibacterial agents, including cleocin hcl and may range in severity from mild diarrhea to fatal colitis. Provides access to the latest drug monographs submitted to the food and drug administration fda. This medication is given by injection into a vein or muscle as directed by your doctor, usually 2 to 4 times a day. Marquette general pharmacy dlp renal dosing protocol drug usual dose crcl adjusted mlmin dose hemodialysis peritoneal dialysis comments acyclovir iv 5 20 mgkg q 8h 25 50 100% of dose q12 h manufacturer suggest 1 l of fluid per gram of drug urine output should be maintained at. When a dosage range is provided, the high dose generally is intended for severe infections. The level of renal function below which the dose of a drug must be reduced depends largely on the extent of renal metabolism and elimination, and on the drugs toxicity. One limitation is that the handbook is a uk publication so some of the drugs and dosing recommendations are not relevant to the australian situation. Drug dosing adjustments in patients with chronic kidney. It also saves pharmacists time, since they can adjust doses themselves according to the most current clinical needs without waiting to hear from physicians. Marquette general pharmacy dlp renal dosing protocol. Renal dosing of antimicrobials gloucestershire hospitals. Cleocin pediatric clindamycin palmitate hydrochloride.
In combination with quinine, it can be used for malaria. Clindamycin 167 clobazam 168 clofazimine 169 clomethiazole chlormethiazole 170. Serious infections 8 to 16 mgkgday 4 to 8 mglbday divided into three or four equal doses. Have pharmacists determine all doses for renal patients. Clindamycin phosphate is administered in the form of an infusion over 1045 minutes, depending on the dose to be administered. If your dose is different, do not change it unless your doctor tells you to do so. Renal dosage adjustment guidelines for antimicrobials the pharmacists will automatically adjust the doses of any of the antimicrobials included in the protocol according to the estimated creatinine clearance generally using the cockroftgault equation for patients. Although no direct relationship of clindamycin to renal damage has been. As an alternative to vancomycin for mrsa infections, the infectious diseases society of america idsa recommends 600 mg iv every 8 hours for 3 to 4 weeks for septic arthritis and for 4 to 6 weeks for osteomyelitis. Cleocin dosage guidelines for acne treatment, cleocin lotion, gel, or solution are usually applied to the skin once a day. Every second drug needs dose adjustment to kidney function. Renal dosage adjustment guidelines for antimicrobials. Clindamycin phosphate an overview sciencedirect topics.
Clinical course of haemodialysis patients with malignancies and doseadjusted chemotherapy. In acute on chronic renal impairment the initial dose should correspond to the previous level of chronic renal impairment. The most current version of the renal dosage adjustment guidelines for antimicrobials and. More severe infections 16 to 20 mgkgday 8 to 10 mglb. The dose of this medicine will be different for different patients.
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